Bone Marrow

Researchers at Aichi Gakuin University have published new data on bone marrow

Published in Blood Weekly, August 16th, 2007

"The effect of neuropeptide Y (NPY), a co-transmitter with noradrenaline in peripheral sympathetic nerve fibers, on the osteoclastogenesis in mouse bone marrow cell cultures treated with isoprenaline, a beta-adrenergic receptor (beta-AR) agonist, was examined. The mouse bone marrow cells constitutively expressed mRNAs for the NPY-Y1 receptor and beta 2-AR," scientists in Nagoya, Japan report.

"NPY inhibited the formation of osteoclast-like cells induced by isoprenaline but not that by 1 alpha,25-dihydroxyvitamin D-3 (1 alpha,25(OH)(2)D-3) or soluble receptor activator of nuclear factor-kappa B ligand (RANKL); and it suppressed the production of RANKL and cyclic AMP...

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Source: Blood Weekly (2007-08-16)

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