Thrombocytopenia

Studies from A. Zenner et al in the area of thrombocytopenia described

Published in Blood Weekly, August 30th, 2007

According to recent research from Rome, Italy, "Thrombocytopenia is a common side effect of chemotherapy, responsible for increased risk of bleeding and delay of treatment schedules in cancer patients. It is currently unknown how chemotherapeutic agents affect platelet production and whether the platelet precursors megakaryocytes represent a direct target of cytotoxic drugs."

"We investigated the effects of chemotherapeutic agents on primary megakaryocytes by using a culture system that recapitulates in vitro human megakaryopoiesis and found that cytotoxic drugs predominantly destroyed megakaryocytic progenitors at early stages of differentiation. Immature...

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Source: Blood Weekly (2007-08-30)

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