Lymphoma
New findings from Medical College of Georgia in the area of lymphoma described
Published in Blood Weekly, September 6th, 2007
Investigators publish new data in the report "Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. A hallmark in the pathogenesis of cancer is the increased expression of heat shock proteins (Hsps) and other molecular chaperones observed in many tumor types, which is considered to be an adaptive response to enhance tumor cell survival. Heat shock transcription factor 1 (Hsf1) is a major transactivator of Hsp induction and has been proposed to affect tumor initiation and progression, regulating expression of Hsps and other molecular targets," scientists writing in the journal Oncogene report.
"In this...
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Source: Blood Weekly (2007-09-06)
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