Leukemia Genetics
Reports outline leukemia genetics study findings from Shanghai Jiao Tong University, Shanghai Institutes of Biological Sciences
Published in Blood Weekly, September 13th, 2007
Researchers detail in "Leukemogenic AML1-ETO fusion protein increases carcinogen-DNA adduct formation with upregulated expression of cytochrome P450-1A1 gene," new data in leukemia. "AML1-ETO fusion protein is a product of chromosome translocation t(8;21) frequently occurred in acute myeloid leukemia (AML), but its sole expression appears to fail to cause overt leukemia in vivo. In this study, we investigated whether AML1-ETO expression impinged on action of chemical carcinogens-DNA adduct formation. AML1-ETO fusion protein was conditionally induced in engineered U937-A/E 9/14/18 cells," investigators in Shanghai, People's Republic of China report.
"The formation of...
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Source: Blood Weekly (2007-09-13)
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