Mastocytosis
Scientists at University of Minnesota detail research in mastocytosis
Published in Blood Weekly, September 13th, 2007
A report, "Vav promoter-tTA conditional transgene expression system for hematopoietic cells drives high level expression in developing B and T cells," is newly published data in Experimental Hematology. According to recent research from the United States, "We previously showed that Vav promoter-tetracycline transactivator (Vav-tTA)-driven tetracycline-regulated element (TRE)-NRAS(V12) expression resulted in mastocytosis development in mice. To investigate which hematopoietic cells express TRE-driven transgenes when combined with Vav-tTA, we assayed hematopoietic cells, including bone marrow-derived mast cells (BMMC) and CD34-positive hematopoietic progenitor cells (HPC) as well as...
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Source: Blood Weekly (2007-09-13)
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