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Unique Mouse Joins Battle Against Dengue Fever

Published in Blood Weekly, September 13th, 2007

A mosquito-borne disease often known as “break-bone fever” has found a new enemy in a unique type of mouse.

The first animal model to test potential treatments for the dengue fever virus – an immuno-suppressed mouse that has been transplanted with human cord blood cells – was developed last year by Dr. Rebeca Rico-Hesse at Southwest Foundation for Biomedical Research. Now, with a new $111,000 pilot study grant from the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, Dr. Rico-Hesse will strive to enhance the model so it can be used to test candidate vaccines and help researchers learn more about immune factors that contribute to varying disease severity among...

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