Transplantation

Research from W.I. Khalife and co-researchers yields new findings on transplantation

Published in Blood Weekly, September 13th, 2007

According to a study from the United States, "Sirolimus is a well-known, potent immunosuppressant that is widely used in solid-organ transplantation, but it is not without potential side effects."

"A rare but devastating adverse effect is sirolimus-associated pulmonary toxicity. We report a case of sirolimus-induced diffuse alveolar hemorrhage confirmed by bronchoscopic findings (after other possible etiologies were ruled out) and by clinical and radiographic resolution of the pulmonary signs and symptoms a few days after sirolimus administration was stopped," wrote W.I. Khalife and colleagues.

The researchers concluded: "This case and the existing...

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Source: Blood Weekly (2007-09-13)

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