Hypertension Therapy
New hypertension therapy study findings recently were published by researchers at University of Montreal, Faculty of Pharmacy
Published in Blood Weekly, September 27th, 2007
Data detailed in "Distinct effects of amlodipine treatment on vascular elastocalcinosis and stiffness in a rat model of isolated systolic hypertension" have been presented. "Medial elastocalcinosis (MEC) contributes to the development of large artery stiffness and isolated systolic hypertension. Since endothelin receptor antagonists can prevent and regress elastocalcinosis, our aim was to determine whether amlodipine, a calcium channel blocker that inhibits endothelin signaling, could likewise influence MEC, or reduce pressure mainly through its vasorelaxing properties," investigators in Quebec, Canada report.
"Control male Wistar rats were compared with rats receiving...
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Source: Blood Weekly (2007-09-27)
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