Graft-Versus-Host Disease

Researchers from University of Paris report recent findings in graft-versus-host disease

Published in Blood Weekly, October 4th, 2007

According to recent research published in the journal Transplantation, "Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties. They are able to suppress allogenic T-cell response and modify maturation of antigen-presenting cells."

"Their role in the treatment of severe graft versus host disease has been reported. The underlying molecular mechanisms of immunosuppression are currently being investigated. Histocompatibility locus antigen (HLA)-G is a nonclassical major histocompatibility complex class I antigen with strong immune-inhibitory properties. We studied the role of HLA-G on MSC-induced immunosuppression. The expression of HLA-G on human...

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Source: Blood Weekly (2007-10-04)

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