Ischemia

Studies conducted at M.S. Delbridge et al on ischemia recently published

Published in Blood Weekly, October 4th, 2007

According to recent research from Sheffield, the United Kingdom, "The current shortage of organ donors has led many centers to use marginal and nonheart-beating donors (NHBDs). Recent research has implicated the infiltration of lymphocytes as an important mediator of ischemia-reperfusion injury (IRI)."

"FTY720 is an immunosuppressant that promotes lymphocyte sequestration into lymph nodes. The purpose of this study was to examine the potential for FTY720 to abrogate IRI when subjected to increasing ischemic times. Male Sprague-Dawley rats under-went bilateral flank incision with removal of the right kidney and clamping of the left hilum. Groups were divided into...

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Source: Blood Weekly (2007-10-04)

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