Study results from Leiden University, Department of Clinical Epidemiology broaden understanding of thrombosis genetics

Researchers detail in 'A genetic basis for the interrelation of coagulation factors,' new data in thrombosis. According to a study from Leiden, Netherlands, "Evidence found in the literature for a strong correlation between coagulation factors suggests that single genes might influence the plasma concentrations of multiple coagulation factors (i.e. pleiotropically acting genes). To determine whether there is a genetic basis for the correlation among coagulation factors by assessing the heritability of interrelated coagulation factors. We performed principal components analysis, and subsequently variance components analysis, to estimate the heritability of principal components of...

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