Biomedicine
Findings in biomedicine reported from Poznan University of Medical Sciences
Published in Blood Weekly, October 18th, 2007
A report, 'Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines,' is newly published data in Biomedicine and Pharmacotherapy. According to a study from Poznan, Poland, "The glucocorticoid receptor (GR) is mainly expressed as nine-exon alternatively spliced variants, encoding functional GRalpha and nonfunctional GRbeta. Overexpression of GRbeta splice variant was found in glucocorticoid-resistant patients with some autoimmune diseases and hematological malignancies."
"Employing reverse transcription, real-time quantitative PCR, and western...
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Source: Blood Weekly (2007-10-18)
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