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Researchers at University of Florida, Department of Pediatrics target life sciences

Published in Blood Weekly, November 8th, 2007

Scientists discuss in 'Sites and kinetics of donor thrombopoiesis following transplantation of whole bone marrow and progenitor subsets' new findings in life sciences. "INTRODUCTION: Little is known about the sites and kinetics of thrombopoiesis following bone marrow transplant. The spleen is a site of hematopoiesis in a healthy mouse, and hematopoietic activity increases in response to stress," investigators in the United States report.

"We hypothesized that the spleen is a major site of early post-transplant thrombopoiesis. We transplanted whole bone marrow (WBM) or lineage depleted progenitor subsets fractionated based on expression of c-kit and Sca-1 from transgenic...

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