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Immunotherapy

Researchers from University of Amsterdam discuss findings in immunotherapy

Published in Blood Weekly, November 15th, 2007

New investigation results, 'Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors,' are detailed in a study published in The Journal of Immunology. "In vitro production of human T cells with known Ag specificity is of major clinical interest for immunotherapy against tumors and infections. We have performed TCRalphabeta gene transfer into human hemopoietic progenitors from postnatal thymus or umbilical cord blood, and subsequently cultured these precursors on OP9 stromal cells expressing the Notch human ligand Delta-like1," investigators in Amsterdam, Netherlands report.

"We report...

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