Published in Blood Weekly, November 15th, 2007
"This finding has been explained, at least in part, by the lack of PML action to modulate retinoic acid-differentiating activities. In this study, we found that CJEBP epsilon expression is reduced in PML-deficient mice. We showed that PU.1 directly activates the transcription of the C/EBPE gene that is essential for granulocytic differentiation. The type IV isoform of PML interacted with PU.1, promoted its association with p300, and then enhanced PU.1-induced...
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