Acute Lymphoblastic Leukemia

Studies from J.B. Nachman et al provide new data on acute lymphoblastic leukemia

Published in Blood Weekly, November 22nd, 2007

According to recent research from the United States, "One-hundred thirty-nine patients with acute lymphoblastic leukemia (ALL) and hypodiploldly (fewer than 45 chromosomes) were collected from 10 different national ALL study groups and single institutions. Patients were stratified by modal chromosome number into 4 groups: 24 to 29 (N = 46); 33 to 39 (N = 26); 40 to 43 (N = 13); and 44 (N = 54) chromosomes."

"Nine patients were Philadelphia chromosome (Ph) positive (4 cases: 44 chromosomes; 5 cases: 40-43 chromosomes) and were not considered further. Event-free survival (EFS) and overall survival (OS) of the remaining 130 patients were 38.5% 4.4% and 49.80/6 4.2% at 8...

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Source: Blood Weekly (2007-11-22)

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