Psoriasis

Data from University of Marburg advance knowledge in psoriasis

Published in Blood Weekly, December 13th, 2007

According to a study from Marburg, Germany, "In common acquired skin disorders with a polygenic background such as psoriasis, a linear or otherwise segmental arrangement may sometimes be noted. The segmental involvement tends to be rather severe and may be associated with milder, nonsegmental lesions of the same disorder."

"Such cases may be best explained by an early postzygotic event in the form of loss of heterozygosity involving one of the genes that predispose to the disorder. The following pertinent examples are reviewed in this article: psoriasis vulgaris, pustular psoriasis, atopic dermatitis, lichen planus, systemic lupus erythematosus, pemphigus vulgaris,...

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Source: Blood Weekly (2007-12-13)

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