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Prothrombin

Findings from University of Colorado broaden understanding of prothrombin

Published in Blood Weekly, December 20th, 2007

"Celiac sprue most commonly presents with steatorrhea, abdominal pain, and weight loss. Celiac disease is now becoming more recognized for its atypical presentations," investigators in the United States report.

"Anemia, osteoporosis, and childhood failure to thrive have been widely discussed. In this paper, we present a case of nontraumatic intramuscular hemorrhage associated with prolongation of both prothrombin time and activated partial thromboplastin time. Coagulopathy, unmasked by the use of a nonsteroidal anti-inflammatory drug, was found to be attributable to vitamin K deficiency associated with malabsorption of multiple fat soluble vitamins. Celiac sprue was...

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