Engineered Heart

Findings in engineered heart reported from University of Hamburg

Published in Blood Weekly, December 27th, 2007

"PKC alpha has been shown to be a negative regulator of contractility and PKCa gene deletion in mice protected against heart failure. Small interfering (si)RNAs mediate gene silencing by RNA interference (RNAi) and may be used to knockdown PKC alpha in cardiomyocytes," researchers in Hamburg, Germany report.

"However, transfection efficiencies of (si)RNAs by lipofection tend to be low in primary cells. To address this limitation, we developed an adenoviral vector (AV) driving short hairpin (sh)RNAs against PKCa (Ad-shPKC alpha) and evaluated its potential to silence PKCa in neonatal rat cardiac myocytes and in engineered heart tissues (EHTs), which resemble functional...

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Source: Blood Weekly (2007-12-27)

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