Antifungals

New findings from B. Yao and co-authors describe advances in antifungals

Published in Blood Weekly, January 31st, 2008

"Novel 2-aminotetralin derivatives were synthesized as antifungal agents. The 2-aminotetralin scaffold was chemically designed to mimic the tetrahydroisoquinoli ne ring of the lead molecule described before," scientists writing in the Journal of Medicinal Chemistry report.

"Their antifungal activities were evaluated in vitro by measuring the minimal inhibitory concentrations (MICs). Compounds 10a, 12a, 12c, 13b, and 13d are more potent than fluconazole against seven testing human fungal pathogens. Compound 10b exhibits much higher antifungal activities against all of the four fluconazole-resistant clinic Candida albicans strains than the control drugs including...

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Source: Blood Weekly (2008-01-31)

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