Xenotransplantion

Research from University of Alberta reveals new findings on xenotransplantion

Published in Blood Weekly, February 14th, 2008

According to a study from Edmonton, Canada, "Neonatal porcine islets (NPI) are a potentially useful source of beta cells for transplantation to treat type 1 diabetes mellitus. However, cytokine exposure following xenotransplantation is likely to prevent successful NPI xenograft survival."

"In this study, we examined the effects of human proinflammatory cytokines (IL-1 beta, IFN gamma, TNF alpha) on NPI function and cell death. These cytokines have been shown to be cytotoxic to beta cells, in part through the generation of nitric oxide. Therefore, we also examined NPI function after acute oxidative stress caused by streptozotocin (STZ), a nitric oxide-generating beta...

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Source: Blood Weekly (2008-02-14)

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