Cancer Therapy

Research from E. Oflazoglu and colleagues has provided new data on cancer therapy

Published in Blood Weekly, February 28th, 2008

According to a study from the United States, "Increased expression of CD30 is associated with a variety of hematologic malignancies, including Hodgkin disease (HD) and anaplastic large cell lymphoma (ALCL). The anti-CD30 monoclonal antibody SGN-30 induces direct antitumor activity by promoting growth arrest and DNA fragmentation of CD30(+) tumor cells."

"In this study, we investigated the contributions of Fc-mediated effector cell functions to SGN-30 activity. We determined that antibody-dependent cellular phagocytosis, mediated by macrophages, to contribute significantly to antitumor activity in vitro. To delineate the identity of the host effector cells involved in...

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Source: Blood Weekly (2008-02-28)

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