Atherosclerosis

Data from H.M. Vanpuijvelde and colleagues advance knowledge in atherosclerosis

Published in Blood Weekly, February 28th, 2008

According to a study from Netherlands, "HSP60-specific T cells contribute to the development of the immune responses in atherosclerosis. This can be dampened by regulatory T cells activated via oral tolerance induction, and we explored the effect of oral tolerance induction to HSP60 and the peptide HSP60 (253 to 268) on atherosclerosis."

"HSP60 and HSP60 (253 to 268) were administered orally to LDLr-/- mice before induction of atherosclerosis and resulted in a significant 80% reduction in plaque size in the carotid arteries and in a 27% reduction in plaque size at the aortic root. Reduction in plaque size correlated with an increase in CD4(+)CD25(+)Foxp3(+) regulatory T...

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Source: Blood Weekly (2008-02-28)

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