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Alpha-thalassemia

Studies from J.D. Lafferty and co-researchers update current data on alpha-thalassemia

Published in Blood Weekly, March 20th, 2008

"Routine laboratories use a hemoglobin H (HbH) screen to detect alpha-thalassemia carriers of fatal hemoglobin Bart's hydrops fetalis. This test is laborious and has sensitivity concerns," scientists in Hamilton, Canada report.

"A commercial zeta-globin enzyme-linked immunosorbent assay (ELISA) is effective in detecting Southeast Asian (SEA) alpha-thalassemia. We present results of a study of the effectiveness of carrier detection of ELISA and a shortened HbH screen compared with gap polymerase chain reaction. ELISA was superior to the HbH screen for the SEA alpha(0)-thalassemia trait. The ELISA and H screen were equal for detection of all carriers encountered and...

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