Myelodysplastic Syndrome

Findings from V.M. Klimek and co-authors broaden understanding of myelodysplastic syndrome

Published in Blood Weekly, March 27th, 2008

According to recent research published in the journal Clinical Cancer Research, "Epigenetic modulation of gene expression plays an important role in cancer, including leukemia. Furthermore, histone deacetylase inhibitors may induce the reexpression or repression of genes critical for normal hematopoiesis."

"The purpose of this study was to evaluate the toxicity, pharmacokinetic profile, and selected pharmacodynamic properties of the histone deacetylase inhibitor depsipeptide in patients with myelodysplastic syndromes (MDS) or acute myelogenous leukemia (AML). Depsipeptide was administered to MDS or AML patients at a (solid tumor) phase I dose of 18 mg/m(2) i.v....

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Source: Blood Weekly (2008-03-27)

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