Monoclonal Antibodies
Researchers from University of Athens, Department of Internal Medicine detail findings in monoclonal antibodies
Published in Blood Weekly, April 3rd, 2008
A new study, 'Monoclonal antibodies in the treatment of lymphoid malignancies,' is now available. According to a study from Athens, Greece, "Rituximab (Rit) was the first monoclonal antibody approved for therapeutic use in cancer patients. Rit is a chimeric mouse/human monoclonal antibody, consisting of the human IgG1 and k constant Fc region, and a mouse variable Fab region specific against the B-cell antigen CD20."
"Rit exerts its antilymphoma activity through many different mechanisms. Binding of antibody to CD20 antigen, provokes apoptosis through downstream signals that lead to caspase-3 activation. Complement activation by the Fc portion of the antibody results in...
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Source: Blood Weekly (2008-04-03)
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