Hematology

New hematology study findings have been published by scientists at University of Oklahoma

Published in Blood Weekly, April 10th, 2008

"Activation of natural killer-like T (NKT) cells with the CD1d ligand alpha-galactosylceramide enhances T-dependent humoral immune responses against coadministered T-dependent Ag. At present, there is little information on the mechanisms involved other than a dependence on CD1d expression by antigen-presenting cells and/or development of the NKT subset," scientists in the United States report.

"We therefore tested the hypothesis that direct presentation of alpha-GC by B cells was required for NKT-enhanced Ab responses against T-dependent Ag. We reconstituted B cell-deficient mu MT mice with B cells from C57BI/6 donors or CD1d(-/-) donors before immunization with NP-KLH...

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Source: Blood Weekly (2008-04-10)

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