Hematology

Study data from University of Western Australia provide new insights into hematology

Published in Blood Weekly, April 10th, 2008

"Hemopoietic lineage switch (His) 5 and 7 were originally isolated as genes upregulated during an erythroid-to-myeloid lineage switch. We have shown previously that HIs7/Mlf1 imposes a monoblastoid phenotype on erythroleukemic cells," investigators in Crawley, Australia report.

"Here we show that Hls5 impedes erythroid maturation by restricting proliferation and inhibiting hemoglobin synthesis; however, HIs5 does not influence the morphology of erythroid cells. Under the influence of GATA-1, HIs5 relocates from cytoplasmic granules to the nucleus where it associates with both FOG-1 and GATA-1. In the nucleus, HIs5 is able to suppress GATA-1-mediated transactivation and...

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Source: Blood Weekly (2008-04-10)

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