Tissue Engineering

Studies from T.A. Beyer et al in the area of tissue engineering described

Published in Blood Weekly, April 10th, 2008

"The liver is frequently challenged by surgery-induced metabolic overload, viruses or toxins, which induce the formation of reactive oxygen species. To determine the effect of oxidative stress on liver regeneration and to identify the underlying signaling pathways, we studied liver repair in mice lacking the Nrf2 transcription factor," scientists in Zurich, Switzerland report.

"In these animals, expression of several cytoprotective enzymes was reduced in hepatocytes, resulting in oxidative stress. After partial hepatectomy, liver regeneration was significantly delayed. Using in vitro and in vivo studies, we identified oxidative stress-mediated insulin/insulin-like...

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Source: Blood Weekly (2008-04-10)

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