Gene Therapy

Research findings from C.W. Knopf et al update understanding of gene therapy

Published in Blood Weekly, April 10th, 2008

Investigators publish new data in the report 'Evaluation of the T-REx transcription switch for conditional expression and regulation of HSV-1 vectors.' According to recent research published in the journal Virus Genes, "Herpes simplex virus 1 (HSV-1) strain ANG and ANGpath were cloned as bacterial artificial chromosome (BAC). Two different types of BAC genomes were obtained."

"BAC genomes of type I contained the BAC replicon at the intended target region between the genes of UL48 and UL49. In BAC genomes of type II, the BAC sequences were found to be aberrantly fused between the termini of the HSV-1 genome. Both the BAC types were used to establish a conditional...

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Source: Blood Weekly (2008-04-10)

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