Neutropenia
Researchers from Cincinnati Children's Hospital report on findings in neutropenia
Published in Blood Weekly, April 10th, 2008
Researchers detail in 'Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1,' new data in neutropenia. "Severe congenital neutropenia (SCN) is characterized by a deficiency of mature neutrophils, leading to recurrent bacterial and fungal infections. Although mutations in Elastase-2, neutrophil (ELA2) predominate in human SCN, mutation of Ela2 in mice does not recapitulate SCN," investigators in the United States report.
"The growth factor independent-1 (GFI1) transcription factor regulates ELA2. Mutations in GFI1 are associated with human SCN, and genetic deletion of Gfi1 results in...
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Source: Blood Weekly (2008-04-10)
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