Acute Myeloid Leukemia
Research from A. Glasow and co-researchers yields new findings on acute myeloid leukemia
Published in Blood Weekly, April 10th, 2008
According to recent research published in the journal Blood, "The retinoic acid receptor (RAR) alpha gene (RARA) encodes 2 major isoforms and mediates positive effects of all-trans retinoic acid (ATRA) on myelomonocytic differentiation. Expression of the ATRA-inducible (RAR alpha 2) isoform increases with myelomonocytic differentiation and appears to be down-regulated in many acute myeloid leukemia (AML) cell lines."
"Here, we demonstrate that relative to normal myeloid stem/progenitor cells, RAR alpha 2 expression is dramatically reduced in primary AML blasts. Expression of the RAR alpha 1 isoform is also significantly reduced in primary AML cells, but not in...
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Source: Blood Weekly (2008-04-10)
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