Lymphoma
Studies from University of California, Department of Nutrition yield new data on lymphoma
Published in Blood Weekly, April 10th, 2008
A report, 'Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations,' is newly published data in Biochemical Pharmacology. "Due to long-term toxicity of current Hodgkin's lymphoma (HL) treatment, the present challenge is to find new therapies that specifically target deregulated signaling cascades, including NF-kappaB, which are involved in Hodgkin (H) and Reed-Sternberg (RS) cell proliferation and resistance to apoptosis. We previously presented evidence that dimeric procyanidin B2 (B2) can interact with NF-kappaB proteins inhibiting the binding of NF-kappaB to DNA," scientists in the United...
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Source: Blood Weekly (2008-04-10)
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