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Angiotensins

New angiotensins study findings reported from University of British Columbia

Published in Blood Weekly, April 10th, 2008

According to recent research published in the journal Neuropeptides, "The objectives of this study were to determine whether endogenous opioids are operative in modulating the CNS action of angiotensin II (ang II) on blood pressure and to determine whether this is mediated by endogenous mu or kappa opioid receptor agonists. The study design was: unanesthetized Wistar rats, 300-400 g, previously instrumented with a cannula in the lateral cerebral ventricle and a catheter in the femoral artery, had ang II, 0.5 mu g, injected into the lateral cerebral ventricle (ICV)."

"Groups were allocated to receive naloxone, a mu opioid receptor antagonist or MR 2266 a selective...

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