Acute Myelogenous Leukemia

Investigators at Massachusetts General Hospital publish new data on acute myelogenous leukemia

Published in Blood Weekly, April 24th, 2008

According to recent research from the United States, "Proteasome inhibition results in cytotoxicity to the leukemia stem cell in vitro. We conducted this phase I study to determine if the proteasome inhibitor bortezomib could be safely added to induction chemotherapy in patients with acute myelogenous leukemia (AML)."

"Bortezomib was given on days 1, 4, 8, and 11 at doses of 0.7,1.0, 1.3, or 1.5 mg/m(2) with idarubicin 12 mg/m(2) on days 1 to 3 and cytarabine 100 mg/m(2)/day on days 1 to 7. A total of 31 patients were enrolled. The median age was 62 years, and 16 patients were male. Nine patients had relapsed AML (ages, 18-59 years, n = 4 and >= 60 years, n = 5)....

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Source: Blood Weekly (2008-04-24)

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