Enzyme Research
New enzyme research study findings recently were published by researchers at University of Barcelona
Published in Blood Weekly, May 1st, 2008
According to recent research published in the journal Proteins - Structure Function and Bioinformatics, "Gaucher disease, the most prevalent lysosomal storage disorder, is principally caused by malfunction of the lysosomal enzyme glucocerebrosidase (GBA), a 497-amino acid membrane glycoprotein that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose in the presence of an essential 84-residue activator peptide named saposin C (SapC). Knowledge of the GBA structure, a typical (beta/alpha)(8) TIM barrel, explains the effect of few mutations, directly affecting or located near the catalytic site."
"To identify new regions crucial for proper GBA...
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Source: Blood Weekly (2008-05-01)
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