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Chronic Lymphocytic Leukemia

Researchers from University of Texas describe findings in chronic lymphocytic leukemia

Published in Blood Weekly, May 1st, 2008

"We evaluated the activity and tolerability of alemtuzumab given as a continuous infusion for 7 d followed by subcutaneous administration for 11 wk as salvage therapy for 10 patients with fludarabine-refractory chronic lymphocytic leukemia. The continuous infusion of alemtuzumab was well tolerated," scientists in the United States report.

"The typical infusion reaction seen with intravenous alemtuzumab was abolished. Two patients achieved a partial response with an overall response rate of 20%. Alemtuzumab levels were measured in four patients and detectable levels were obtained in three," wrote A. Ferrajoli and colleagues, University of Texas.

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