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Hematopoietic

Recent studies from Niigata University add new data to hematopoietic

Published in Blood Weekly, May 1st, 2008

According to recent research from Niigata, Japan, "Macrophages exist in almost all animals. In some invertebrates, mesenchymal cells, endothelial cells or fibroblast-like cells can transform into macrophages."

"In vertebrates, primitive macrophages first develop in yolk sac hematopoiesis and differentiate into fetal macrophages. Monocytes are differentiated from hematopoietic stem cells in the late stage of fetal hematopoietic organs and bone marrow. Macrophages serve as an effector in metabolism and host defense. Depletion of macrophages severely reduced bilirubin production and host resistance to infection. Macrophage scavenger receptors are involved in host defense....

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