Published in Blood Weekly, May 1st, 2008
"In vertebrates, primitive macrophages first develop in yolk sac hematopoiesis and differentiate into fetal macrophages. Monocytes are differentiated from hematopoietic stem cells in the late stage of fetal hematopoietic organs and bone marrow. Macrophages serve as an effector in metabolism and host defense. Depletion of macrophages severely reduced bilirubin production and host resistance to infection. Macrophage scavenger receptors are involved in host defense....
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