Published in Blood Weekly, May 1st, 2008
"Cinacalcet steady state oral clearance was 131.1 +/- 20.9 l/h and 92.8 +/- 9.5 l/h (mean +/- SE) after 30 and 60 mg, respectively. Cinacalcet and parathyroid hormone (PTH) concentrations showed an inverse correlation and were fitted to a simple E-max model (E-max = 80% reduction vs. baseline, EC50 = 13 ng/mL). A once daily administration of cinacalcet lowered...
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