Kidney Disease

Researchers from Yale University, Medical Department publish findings in kidney disease

Published in Blood Weekly, May 1st, 2008

"We previously identified renalase, a secreted novel amine oxidase that specifically degrades circulating catecholamines. Parenteral administration of either native or recombinant renalase lowers blood pressure, heart rate, and cardiac contractility by metabolizing circulating catecholamines," scientists in the United States report.

"Renalase plasma levels are markedly reduced in patients with chronic kidney disease. It is not known whether endogenous renalase contributes to the regulation of catecholamines. We show here that circulating renalase lacks significant amine oxidase activity under basal conditions (prorenalase) but that a brief surge of epinephrine lasting...

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Source: Blood Weekly (2008-05-01)

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