Obesity and Diabetes
Research from P.J. Larsen et al has provided new information about obesity and diabetes
Published in Blood Weekly, May 1st, 2008
"Severe insulin resistance and impaired pancreatic beta-cell function are pathophysiological contributors to type 2 diabetes, and ideally, antihyperglycaemic strategies should address both. Therapeutic benefits of combining the long-acting human glucagon-like peptide-1 (GLP-1) analog, liraglutide (0.4 mg/kg/day), with insulin sensitizer, pioglitazone (10 mg/kg/day), were assessed in severely diabetic Zucker diabetic fatty rats for 42 days," scientists in Copenhagen, Denmark report.
"Impact on glycaemic control was assessed by glycated haemoglobin (HbA(1C)) at day 28 and by oral glucose tolerance test at day 42. Liraglutide and pioglitazone synergistically improved...
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Source: Blood Weekly (2008-05-01)
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