Pharmacokinetics

Findings from University of Rostock broaden understanding of pharmacokinetics

Published in Blood Weekly, May 1st, 2008

According to a study from Rostock, Germany, "For more than three decades, acetaminophen ( INN, paracetamol) has been claimed to be devoid of significant inhibition of peripheral prostanoids. Meanwhile, attempts to explain its action by inhibition of a central cyclooxygenase (COX)-3 have been rejected."

"The fact that acetaminophen acts functionally as a selective COX-2 inhibitor led us to investigate the hypothesis of whether it works via preferential COX-2 blockade. Ex vivo COX inhibition and pharmacokinetics of acetaminophen were assessed in 5 volunteers receiving single 1000 mg doses orally. Coagulation-induced thromboxane B-2 and lipopolysaccharideinduced...

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Source: Blood Weekly (2008-05-01)

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