Leukemia Therapy
Reports outline leukemia therapy research from St. James's University, Leeds Institute of Molecular Medicine
Published in Blood Weekly, May 1st, 2008
Data detailed in 'Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias' have been presented. According to recent research from Leeds, the United Kingdom, "Mouse models of human cancer are a potential preclinical setting for drug testing and for development of methods for delivery of macromolecular drugs to tumors. We have assessed a mouse model of leukemia caused by Mll-Enl protein fusion as a preclinical situation in which myeloid-lineage leukemia results from de novo occurrence of chromosomal translocations between Mll and Enl genes."
"Here, we show that the mouse leukemias respond to cytosine arabinoside, a frontline treatment...
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Source: Blood Weekly (2008-05-01)
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