Fibrinolysis

New fibrinolysis research reported from R.J. Seitz and co-authors

Published in Blood Weekly, May 8th, 2008

"The goal of acute stroke therapy is to salvage brain tissue by rapid cerebral artery recanalization to improve microcirculation. A major drawback of fibrinolysis is the activation of platelets leading to a high rate of re-occlusion," researchers in Dusseldorf, Germany report.

"Antagonists of the platelet GPIIb/IIIa-receptor inhibit the binding of fibrinogen to platelets counteracting secondary thrombus formation. Also, they were shown to suppress thrombembolus formation and to limit lesion development in cerebral ischemia. We review the literature concerning the use of intravenously administered GPIIb/IIIa-receptor antagonists abciximab, eptifibatide and tirofiban for...

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Source: Blood Weekly (2008-05-08)

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