Life Sciences
Reports outline life sciences study findings from Imperial College London, Department of Life Sciences
Published in Blood Weekly, May 29th, 2008
Researchers detail in 'Structural insight into Slit-Robo signalling,' new data in life sciences. "Drosophila Slit and its vertebrate orthologues Slit1-Slit3 are secreted glycoproteins that play important roles in the development of the nervous system and other organs. Human Slits are also involved in a number of pathological situations, such as cancer and inflammation," investigators in London, the United Kingdom report.
"Slits exert their effects by activating receptors of the Robo (Roundabout) family, which resemble cell adhesion molecules in their ectodomains and have large, mainly unstructured cytosolic domains. HS (heparan sulfate) is required for Slit-Robo...
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Source: Blood Weekly (2008-05-29)
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