Apoptosis

New apoptosis research from Toyama University described

Published in Blood Weekly, May 29th, 2008

According to a study from Toyama, Japan, "The aim of this study was to examine whether, a new synthesized class of benzocycloalkene derivatives (BCs), enhances apoptosis induced by hyperthermia. The combined effects of hyperthermia (44 degrees C, 20 min) and BCs on apoptosis in human lymphoma U937 cells were investigated."

"Among the tested compounds (BC1 similar to 9), the combined treatment of 10 mc M BC2 or BC4 and hyperthermia showed the largest potency to induce DNA fragmentation at 6 h after hyperthermia. And enhancement of hyperthermia-induced apoptosis by BC2 or BC4 in a dose-dependent manner was observed. When the cells were treated first with BC2 or BC4 at a...

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Source: Blood Weekly (2008-05-29)

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