Life Sciences

Research from J.G. Tardos and colleagues provide new insights into life sciences

Published in Blood Weekly, June 5th, 2008

"Human monocytes express two naturally occurring forms of circulating tissue factor (TF) - full-length TF, a membrane-spanning protein, and alternatively spliced TF, a soluble molecule. Presence of the variable exon 5 in TF mRNA determines whether the encoded TF protein is transmembrane, or soluble," scientists writing in the Journal of Thrombosis and Haemostasis report.

"Recently, an essential SR protein ASF/SF2 was implicated in TF pre-mRNA processing in human platelets. To examine molecular mechanisms governing regulated processing of TF pre-mRNA in human monocytic cells. In silico analysis of the human TF exon 5, present only in full-length TF mRNA, revealed...

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Source: Blood Weekly (2008-06-05)

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