Inflammatory Bowel Disease
Scientists at Karolinska University target inflammatory bowel disease
Published in Blood Weekly, June 19th, 2008
According to recent research published in the Journal of Gastroenterology, " Impaired immunological tolerance to commensal enteric flora is considered one possible pathogenic mechanism of inflammatory bowel disease (IBD). Given that regulatory T cells and Toll-like receptor (TLR)-positive cells are key actors in mucosal immune regulation, we aimed to identify the dynamics of these actors in the intestinal mucosa in relation to clinical improvement following selective leukapheresis treatment."
"Ten patients with active IBD despite treatment with corticosteroids, immunomodulators, or anti-tumor necrosis factor therapy were assessed by immunohistochemical staining...
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Source: Blood Weekly (2008-06-19)
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