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Ischemia

Research findings from University of Milan update understanding of ischemia

Published in Blood Weekly, June 19th, 2008

According to a study from Milan, Italy, "Irreversible myocardial injury is a potential consequence of coronary artery revascularization. Reperfusion leads to the production of oxidized products that can damage myocardium."

"High-density lipoproteins (HDL) are effective at removing oxidized lipids. We hypothesized that a synthetic HDL preparation, comprising recombinant apolipoprotein A-I-Milano (apoA-I-M) complexed with 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC) (apoA-I-M/POPC) would protect the heart from reperfusion injury. The ex vivo model consisted of rabbit hearts perfused by the Langendorff method. Hearts were equilibrated with Krebs-Henseleit buffer (10...

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