Published in Blood Weekly, June 19th, 2008
"High-density lipoproteins (HDL) are effective at removing oxidized lipids. We hypothesized that a synthetic HDL preparation, comprising recombinant apolipoprotein A-I-Milano (apoA-I-M) complexed with 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC) (apoA-I-M/POPC) would protect the heart from reperfusion injury. The ex vivo model consisted of rabbit hearts perfused by the Langendorff method. Hearts were equilibrated with Krebs-Henseleit buffer (10...
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