Myeloma

Study data from K. Ishitsuka et al provide new insights into myeloma

Published in Blood Weekly, June 26th, 2008

According to recent research published in the British Journal of Haematology, "The interaction between multiple myeloma (MM) cells and the bone marrow (BM) microenvironment induces proliferation and survival of MM cells, as well as osteoclastogenesis. This study investigated the therapeutic potential of novel p38 mitogen-activated protein kinase (p38MAPK) inhibitor LY2228820 (LY) in MM."

"Although cytotoxicity against MM cell lines was modest, LY significantly enhanced the toxicity of bortezomib by down-regulating bortezomib-induced heat shock protein 27 phosphorylation. LY inhibited interleukin-6 secretion from long term cultured-BM stromal cells and BM...

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Source: Blood Weekly (2008-06-26)

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